A set of structurally diverse [(aryl)hepta-1,6-diene-3,5-dione]s (curcuminoids) were synthesized by the reaction of 2,5-pentanedione with the appropriate aldehyde in the presence of tributylborate and n-butylamine as catalyst. These curcuminoids were used as mono-anionic bidentate ligands in the synthesis of half-sandwich organometallic ruthenium complexes of the type [(?6-arene)Ru(curcuminoid)Cl] where arene = benzene or p-cymene. The complexes have been characterized and initial investigations of reactions with DNA as well as some model proteins have been carried out. A number of the complexes show a weak ability to uncoil pBR322 plasmid DNA but this ability disappears under irradiation with 365 nm UV light. Spectroscopic and viscometric experiments suggest that the complexes interact with DNA via weak intercalation. On the other hand the interaction, as measured by the binding constant, with human serum albumin is strong.

Curcuminoids as ligands in half-sandwich organometallic ruthenium piano-stool complexes: Synthesis and biophysical reactivity

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.