The aluminum-catalyzed MPV reduction of carbonyl substrates to alcohols is sustainable, highly chemoselective, operationally simple and uses isopropanol as an inexpensive and non-toxic reducing agent. However, due to high catalyst loadings often required, it has not found widespread utility in synthetic chemistry. Here, we report on the synthesis of bulky cyclic and acyclic aluminum siloxides and their utilization as exceedingly active pre-catalysts in the MPV reduction of ketones and aldehydes under mild and solvent-free conditions with low catalyst loadings.

Bulky aluminum siloxides: Highly efficient catalysts in the Meerwein-Pondorf-Verley (MPV) reduction of aldehydes and ketones

245th National Meeting (2013)

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