The multicomponent compositions of the new genre of bimetallic-based metallating agents offer several Lewis acidic and Lewis basic enticements for attracting substrate molecules. Aside from enticing the substrate molecule to take part in a reaction, the metallating agent with its multi Lewis character is well equipped to capture the resulting anion following the deprotonation. Sensitive anions can therefore be stabilised and potentially primed for synthetic utilisation using this approach.This presentation outlines our recent work in this cleave and capture chemistry using alkali metal zinc and alkali metal aluminium systems. We discuss how combining the Schlosser-Lochmann superbase, nBuLi.KOtBu, with Zn(TMP)2 can deconstruct tetrahydrofuran converting it to pentanedienoic acid. Reactions in which methylanisoles are metallated either in ring or lateral positions and captured are also described. Furthermore we show how a cleaved dimethylamido fragment can be captured by bimetallic base residues on reacting bimetallic bases with the sensitive amine 2-phenylethylamine PhCH2CH2NMe2.

Cleave and capture in heterobimetallic main group chemistry

245th National Meeting (2013)

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