Bacterial nanocellulose (BNC) is emerging biomaterial which combines the nanofibril network with hydrogel like behavior which makes it ideal for Tissue Engineering applications.  In the present study we describe a novel biofabrication method, which uses the bacterial machinery to engineer 3D BNC scaffolds with features at different length scales � ranging from the nano, subcellular to the macroscale. Examples of 3D BNC scaffolds prepared in our laboratory include multichannel BNC for preparation of microvascular structures, highly porous 3D structures for growth of cartilage tissue and combination of  3D multichannel scaffold with highly porous architecture for growth of vascularized tissue such as bone and adipose tissue. 3D BNC scaffolds have shown to support neural network development and enable stem cell differentiation. Human tissues grown on 3D BNC scaffolds show great potential of this new biomaterial-cell constructs for applications in reconstructive surgery and as in vitro model of diseases such as Alzheimer and Osteoarthritis.

Biofabrication of 3D bacterial nanocellulose scaffolds with controlled micro-architecture for growth of autologous human tissue for reconstructive surgery and diagnostics

245th National Meeting (2013)

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