Over the past years, biotechnology has advanced in the development of biomaterials for tissue regeneration and for their utilization as medical devices. In this context, bacterial cellulose (BC)-based membranes have shown promising results in tissue regeneration that can be used in the healing of skin wounds, grafts, drug delivery systems and tissue engineering. Also, the Institute of Chemistry in Araraquara (IQ UNESP) has developed BC composites for utilization as contact lenses. It is intended to incorporate drugs into these contact lenses, such as ciprofloxacin and sodium diclofenac, to improve their therapeutic properties. In order to ensure the safe use of these composites by the medical device industry, it is necessary to evaluate whether those materials have cytotoxic, genotoxic and mutagenic effects. Besides cytotoxicity, it is very important to evaluate the genotoxic and mutagenic potential of these materials, because, if they provide such risks, they can induce cellular modifications in the surrounding tissue, with possible progression to tumor formation (carcinogenesis). After performing in-vitro tests such as XTT, clonogenic surveillance, comet and micronucleus, the results were submitted to statistical analyses. The information regarding the toxic potential of the materials is essential for their safe release for future use in the medical device industry.

Cytotoxic, genotoxic, and mutagenic evaluations in materials based on bacterial cellulose for medical devices

245th National Meeting (2013)

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