The cointrol of glycopolymer arcitecture can improve recognition to appropriate lectins. We will be presenting the use of controlled radical polymerisation (SET LRP) to give sequence control of sugar epitopes in polymers with controlled aritecture. This sequence control allows for the dialing in of sugar sequences for enhanced recognition. The use of appropriate initiators enable us to make glycopolymers available for conjugation to therapeutic petpides and proteins. In particular substitued maleimides show excellent insertion into disulfide bridges thus maintaining tertiary structure. The combination of these give a very powerful method for the synthesios and use of glycopolymers. This presentation will outline our recent work in this area designed to inhibit virius recogniton.

Sequence and polymer architecture control of glycopolymers with enhanced DC-SIGN recognition

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.