Undergraduate community college students worked together to design, develop, implement, and test a procedure for the first semester organic chemistry laboratory class which implements valuable hands-on experience with LC-MS instrumentation. The relatively simple and cost effective quantitative analysis of nonprescription analgesic drugs was selected to meet the following criteria.  The procedures developed fit within the standard 4 hour lab period and fit within the standard lab curriculum, including TLC analysis and use of serial dilution to create standards for quantitative analysis with linear regression. The experiment developed was also integrated appropriately with the curriculum of the first semester organic chemistry course, including the topics of functional group identification, polar-nonpolar interactions and MS fragmentation. Finally, the lab creates an awarenes for the worldwide problem of counterfeit drugs and was designed to relate to students interests; in particular, students who are on the pre-medical, pre-dental, and pre-pharmacy track.

Introduction of HP-LC instrumentation to undergraduate students by quantitative analysis of caffeine and common analgesic drugs in locally available OTC formulations

245th National Meeting (2013)

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