Conformability to tissues and adequate mechanical strength are clinically useful properties of resorbable biomaterials used in soft tissue repair. Here we show that controlled oxidation of microbial cellulose sheets that have been pre-irradiated with ?-radiation results in a resorbable and fully conformable membrane that can be rapidly rehydrated in aqueous fluids.  In vitro studies showed that degradation of the resorbable membranes occurs in two major phases: (1) initial rapid degradation of about 70-80% of the entire sample followed by (2) slower degradation of an additional 5-10% which eventually levels off leaving a small amount of nonresorbable material.  In vivo, prototype materials showed marked degradation at all time points, with the most rapid degradation occurring in the first 2-4 weeks. The inflammatory reaction to the test devices was mild to moderate and was most prominent at the early time points, consistent with a rapidly absorbed material.

Oxidation of γ-irradiated microbial cellulose results in a bioresorbable, highly conformable novel biomaterial

245th National Meeting (2013)

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