Virus-like particles (VLPs) are easily modified by chemical and biological means, retaining excellent properties of stability and structural homogeneity. We have explored the bacteriophage Q-beta capsid as a prototypical VLP for the development of biologically-active entities and assemblies. The synthesis of polymer- and carbohydrate-decorated particles will be described, along with the characterization of their physical, circulatory, and immunological properties relevant to the development of vaccines and diagnostic agents.

Virus particle-based materials: Engineering and biological activity

245th National Meeting (2013)

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