Non-invasive radiofrequency (RF) field-induced targeted hyperthermia using nanoparticles is a departure from conventional cancer treatment modalities.  We have delivered metallic nanoparticles targeted to cancer cells, then exposed the cells to a non-invasive radiofrequency field to produce thermal injury. Both carbon (C60) and gold nanoparticles are not toxic in vitro or in vivo to cancer cells or normal tissues.  However, cancer cells treated with these nanoparticles and then exposed to a non-invasive radiofrequency field demonstrate thermal dose-related cytotoxicity.  Radiofrequency field treatment of animals treated with the targeted nanoparticles leads to significant antitumor response in hepatocellular cancer models.  More complex conjugations are now being performed to include very low doses of cytotoxic agents onto the surface of nanoparticles.  As a result of the cancer cell specific targeting, there is no chemotherapy-related toxicity, but there is significant synergistic enhancement of cytotoxicity combining RF-induced hyperthermia with the cytotoxic agent.

Targeted nanoparticles for non-invasive hyperthermia in malignant disease

245th National Meeting (2013)

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