Ruthenium complexes have yielded many useful drugs, particularly for anticancer treatments.  Ruthenium complexes containing the planar ligand, dppz (Dipyrido [3,2-a:2',3'-c]phenazine), bind strongly to DNA. This reaction can be exploited to chaperone functional groups free radical species to DNA, potentially leading to strand cleavage. One such functional group is NO2-, which is in acid-base equilibrium with NO+.  Under physiological conditions, the NO+ will be reduced, providing the free radical NO. The first research goal is to prepare the ruthenium [Ru(tpy)(dppz)(NO2)]+.  The second goal is to characterize the equilibrium and kinetics interconverting the nitro and nitrosyl ligand.  The third goal is study the complex-DNA binding process. The results of steady-state and time-resolved absorption spectroscopy measurements and their analysis will be reported.

Equilibrium and kinetics of the nitro-nitrosyl-nitroxide interconversion of [Ru(tpy)(dppz)(NO<sub>2</sub>)]<sup>+</sup> in model physiological media

245th National Meeting (2013)

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Equilibrium and kinetics of the nitro-nitrosyl-nitroxide interconversion of [Ru(tpy)(dppz)(NO2)]+ in model physiological media

Equilibrium and kinetics of the nitro-nitrosyl-nitroxide interconversion of [Ru(tpy)(dppz)(NO₂)]⁺ in model physiological media