Pegylated chlorin photosensitizers have been synthesized with triethylene glycol attached at the ester bond(s) for a 1:1 conjugate, a 2:1 conjugate, and a 3:1 conjugate.  These chlorin sensitizers were studied for hydrolytic stability and solubility.  Our studies included an analysis of ovarian OVCAR-5 cancer cell uptake, localization, and phototoxicity.  Because of our interest in fiber-based photosensitizer and singlet oxygen delivery methods, desirable aspects of the 3:1 PEG chlorin conjugate make it a potential sensitizer for incorporation into a fiber optic device, particularly in the area of ovarian cancer photodynamic therapy

Synthesis and characterization of PEGylated chlorin sensitizers for the photodynamic killing of human ovarian cancer cells

245th National Meeting (2013)

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