The current interest in the synthesis of a,�-unsaturated dibenzylidene ketones such as (2E, 6E)-2,6-bis(3-bromobenzylidene)cyclohexanone 1  is their antitumor properties. Although there is sufficient literature supporting these properties, there are a limited number of reactivity studies of such compounds. The goal of this project focuses on kinetic studies of 1 . Kinetic data will be collected using UV-Vis spectroscopy which will follow the reaction of 1  with varying concentrations of potassium hydroxide solutions in aqueous acetonitrile to determine the reactivity of the �-carbon. Preliminary kinetic results will be presented.

Kinetics of reaction of potassium hydroxide with 2,6-bis(3-bromobenzylidene) cyclohexanone in 50% acetonitrile - 50% water

245th National Meeting (2013)

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