A series of selected esters were submitted to conditions that lead to either on the acyl group, or an Sn2 attack on the alcohol portion of the ester.  Organocatalysts have been developed that influence the product ratios towards the Sn2 attack.  The nature of the catalysts will be explored in addition to the substrate scope and possibilities in more complex syntheses.

Organocatalysis of ester cleavage

245th National Meeting (2013)

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