The development of new methods of drug delivery is a field that has garnered great importance with time. Difficulties such as solubility and stability in the medium have inspired the creation of techniques that can improve the handling properties in drug delivery systems. Amongst these, dendrimers and biodegradable polymers are some of the most prominent. We reported thermoresponsive supramolecular G-quadruplexes made from 8-aryl-2'-deoxyguanosine (8ArG) derivatives that form microglobules capable of encapsulating the anti-cancer drug doxorubicin. More recently, we have developed similar systems that are pH-responsive, which make them potentially more suitable for drug encapsulation and delivery applications. We will present the results of encapsulation studies (using primarily fluorescence microscopy and sedimentation experiments) of anticancer drugs doxorubicin, camptothecin and tamoxifen using this new pH-responsive system. We will present the synthesis of the 8ArG imidazole derivative and characterization of the microglobules via NMR (1D/2D), Differential Scanning Calorimetry, Dynamic Light Scattering, and Mass-Spectrometry.

Drug encapsulation studies with microglobules made from pH-responsive supramolecular G-quadruplexes

245th National Meeting (2013)

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