Dihydrobenzoxathiin-derived compounds with variable amino side chains were prepared and evaluated for anti-estrogen activity. Structure-activity relationship with regard to substitutions and amino moieties will be discussed. Compounds displayed good selectivity for affinity of ERa over ER�, and were highly potent in the inhibition of human carcinoma MCF-7 cell growth.

Aromatic amines as potent inhibitors selective for estrogen receptor α over β

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.