The diversity of nitric oxide (NO) effects seems to be related to the concentration and among others it can trigger pro- and antitumor responses characteristics. The ubiquity of NO could be beneficial if its concentration is regulated by using a NO donor agent. This work describes the photochemical and photobiological studies of some nitrosyl ruthenium complex type [RuL5NO]n+ and [RuL5NO]�antibody used as NO deliver system as putative system to improve photodynamic therapy. Photochemical studies shows that nitrosyl ruthenium complexes are capable to produce NO and singlet oxygen, which can act synergistically to produce cytotoxicity against murine melanoma cell line B16F10. The cell viability was found between 10-25 % with 5 J/cm of potency in ligh irradiation. The initial studies suggested us the NO production increases the sensitivity of the cells to singlet oxygen. The synergistic effect of NO and 1O2 may improve Photodynamic Therapy. Acknowledgements.  Fapesp, CNPq and CAPES

Modeling photo-cytotoxicity activity of a nitric oxide and singlet oxygen donor agents by visible light irradiation of ruthenium complexes in melanoma cancer cells

245th National Meeting (2013)

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