With the growth in global population leading to ever increasing demands for food production, the need for effective crop protection agents is paramount. A major issue with existing methods is the rise in herbicide resistance, in particular multiple herbicide resistance (MHR) which is the acquired ability of a weed species to survive herbicide application, regardless of the mode of action or chemotype. One example is that of black grass (Alopecurus myosuroides), known to affect cereal crop yields worldwide.  When compared with herbicide-susceptible black grass, populations showing MHR exhibit significant enhancement of the antioxidant response, in particular elevated expression of a specific GST (AmGSTF1). This protein has been structurally characterised and transformed into Arabidopsis thaliana where it induced an MHR-like phenotype. These results enable ideas of the mode-of-action to be developed and lead to the potential for the reversal of the MHR response using small molecules adjuvants.

Chemical tools for investigating multiple herbicide resistance (MHR) in black grass (<i>Alopecurus myosuroides</i>)

245th National Meeting (2013)

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Chemical tools for investigating multiple herbicide resistance (MHR) in black grass (Alopecurus myosuroides)