The goal of this research was to determine the interaction of certain antibiotics with gold nanostructures (GNS) and silver nanostructures (SNS) though utilization of surface-enhanced infrared absorption spectroscopy (SEIRA). Metal nanostructures were formed on CaF2 plates by vacuum evaporating gold or silver. After the NS were deposited onto the CaF2 plates, the films were characterized by UV/Vis-NIR spectroscopy. Antibiotics investigated are Levofloxacin, Pyrazinecarboxamide, Ciprofloxacin, Isoniazid, D-cycloserine, (+)-6-Aminopenicillanic acid, Metronidazole, and Nalidixic acid. Each antibiotic was deposited onto the nanostructures to determine the degree of vibrational enhancement in SEIRA. Density Functional Theory (DFT) calculations were simulated to analyze the interaction of the antibiotics to the GNS and SNS, which were then compared to the experiments. The impacts of this research will influence biological and medical related applications.

Deposition of antibiotics on silver and gold nanostructures

245th National Meeting (2013)

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