In this study, electrospinning process was used to form porous silica nanofibers prepared by using polyvinyl pyrrolidone (PVP) as a thickener. The PVP was later removed by a heating process to yield the three-dimensional porous silica nanofibers, which were further modified by a biologically active functional groups to form the biocompatible scaffolds. To test the biocompatibility of this porous silica nanofibers, viability, growth and differentiation of neuron-like PC12 cells were assessed. Our results showed that the modified porous silica nanofibers were not only nontoxic to the PC12 cell but also allows for the neuron-like cell to grow and differentiate. This study indicates that the functionalized porous silica nanofibers can be promising biological scaffold materials for the regeneration of neuronal system.

Differentiation of PC12 cells on bioactive 3D porous silica nanofiber scaffolds

245th National Meeting (2013)

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