In an effort to detect anions, specifically halides, novel colorimetric molecular indicators were designed and synthesized.  Initially, several functional motifs were probed through a synthetic survey.  The initial data from these studies led to further synthesis development and characterization of novel azo dyes.  Our particular functional interest focused on several derivatives of the nitroaniline and amino benzoic acid substitutions. Modifications have been made to the initial reaction scheme in aqueous solution because of poor product yield and difficulties with purification.   The alternate conditions eliminated a majority of the water from the reaction and resulted in increase product yield and promising spectral data.  Further variations have also been made to the nucleophile in the synthesis of azo coupling to increase the purity and solubility of the dye.  Investigation of chromatography and crystallization techniques is ongoing with the goal of a clean isolation.

Development of azo coupling synthetic methods for colorimetric indicators

245th National Meeting (2013)

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