Many theranostic systems depend on triggers from biologically-relevant stimuli, e.g. pH or reducing environments, to effect the release of a payload or the activation of imaging modalities. We present progress toward a set of universal, stimuli-responsive organoalkoxysilanes cleaved under either acidic or reducing conditions for use with silica theranostic agents. These silanes contain either an azide or a terminal alkyne, making them reactive in the azide/alkyne �click� reaction with many potential payloads. Moreover, we are interested in fluorine-containing groups for use in 19F MRI with �switch-on� imaging triggered by biological stimuli. Thus, we have additionally developed cleavable and non-cleavable fluorine-containing alkoxysilanes for modifying silica particles with fluorine atoms. Here, we present proof-of-principle studies showing that 19F NMR can be used to detect fluorine atoms immobilized to porous silica nanoparticles.

Stimuli-responsive linkers for use in silica theranostic materials and application to <sup>19</sup>F MRI “switch-on” imaging

245th National Meeting (2013)

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Stimuli-responsive linkers for use in silica theranostic materials and application to 19F MRI “switch-on” imaging

Stimuli-responsive linkers for use in silica theranostic materials and application to ¹⁹F MRI “switch-on” imaging