Compounds containing the carboline substructure exhibit a variety of important medicinal properties, including antibiotic, anti-inflammatory, and antitumor activities. Recently, our laboratory reported the synthesis of pyrazolopyridines via cyclization of 3-acylpyridine N-oxide tosylhydrazones, and it was envisioned that the application of this strategy to the cyclization of 3-(2-aminoaryl)pyridine N-oxides could provide a versatile synthesis of a- and ?-carbolines (Figure). In this presentation, we will discuss our efforts in this area.

Preparation of carbolines via cyclization of 3-(2-aminoaryl)pyridine <i>N</i>-oxides

245th National Meeting (2013)

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Preparation of carbolines via cyclization of 3-(2-aminoaryl)pyridine N-oxides