Recently, several novel benzisoxazolo[2,3-a]pyridinium tetrafluoroborates were synthesized in our laboratory and subsequently found to exhibit some cytotoxicity toward HCT 116 colon cancer cells, presumably due to DNA intercalation. Preliminary computer modeling results suggest that tetracyclic analogs will bind more effectively to DNA, therefore we are developing the synthesis of a series of benzisoxazolo[2,3-a]quinoxalinium salts (Figure) to evaluate their cytotoxicity. In this presentation, we will discuss our efforts toward the synthesis of these compounds.

Synthesis of benzisoxazolo[2,3-a]quinoxalinium tetrafluoroborates

245th National Meeting (2013)

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