Numerous bacterial strains have become immune to the currently available antibiotics. Thus, the need for synthesis of novel antibiotics that are designed to combat multi-drug resistant bacteria is imperative. Recently, the use of Molecular Topology (MT) has been implemented to construct uniquely structured chemical compounds. This revolutionary technology correlates chemical structure to molecular activity to design theoretical compounds with very high antibacterial properties. The research performed utilized a novel synthetic route to develop an antibiotic that Medisyn Technologies Inc. predicted to be effective at combating multi-drug resistant bacteria. The target molecule was successfully synthesized in five steps and tested for potency against the bacterial strains Staphylococcus aureus and Escherichia coli utilizing MIC and Kirby-Bauer tests. Three derivatives of the antibiotic were also synthesized and tested for potency following similar routes and tests.

Synthesis of a topologically designed novel antibiotic

245th National Meeting (2013)

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