In the human immunodeficiency virus (HIV) replication life cycle, the capsid protein has been identified as an attractive inhibition site due to its role in the formation of the capsid core which is crucial for viral infectivity. To date, more than 200 small molecules have been screened for their inhibition activity using {1H, 15N} HSQC titrations. Using a structure activity relationship (SAR) analysis, several synthetic targets were identified. The results of the SAR analysis as well as synthesis and binding data for the capsid protein inhibitors will be presented.

Synthesis of HIV-1 capsid protein inhibitors

245th National Meeting (2013)

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