Cyclic amines are important compounds used as intermediates for the synthesis of pharmaceutical products for the treatment of Alzheimer, Parkinson and other degenerative neurological diseases. Representative benzazepine analogues were prepared by the reduction of O-silylated oximes using BF3-etherate /borane. Other benzazepines derivatives that can enhance the allosteric positive modulation of the a-7 nicotinic acetylcholine receptor are under study. Computer modeling is aimed to determine the compounds that better fit the binding site of these receptors. PM3 (HyperChem) and DFT[B3LYP/6-31G (d) (Gaussian 03) quantum methods are used to determine the thermodynamic parameters. The binding sites and energy of these benzazepine analogs to AChR is currently being studied using the molecular modeling programs AutoDock Tools and AutoDockVina.

Synthesis of 1-benzazepines as nicotinic acetylcholine agonist

245th National Meeting (2013)

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