Dipicolinic acid (DPA) has been shown to have strong chelating capabilities in polar solvents with various metals. DPA lacks hydrophilicity therefore it is pertinent to modify the structure in order to maximize chelating effects. Structure activity relationships (SAR) will allow us to identify the fundamental bonding characteristics of DPA through various modifications aiding in the optimization of DPA solubility in polar solvents, in turn improving binding to metals. In this research we utilized synthetic chemistry to modify DPA for SAR studies in aqueous solutions.

Optimization of solubility and chelating effects of dipicolinic acid

245th National Meeting (2013)

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