Over the last several decades, the synthesis of modified nucleosides has aided in the understanding of deoxyribonucleic acid structure and function. Synthetic modifications have focused on the phosphate backbone, ribose ring or nucleobase.Our research is focused on nucleobase modifications, specifically the synthesis of novel 5-aryl modified thymidine analogues. Recently, nitrogen containing heterocycles such as pyridine and pyrimidine have been successfully attached to the uridine core via Suzuki coupling. These nucleosides will later be site-specifically incorporated into short oligonucleotide sequences for biophysical investigations.

Synthesis of 5-aryl modified nucleosides

245th National Meeting (2013)

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