The biological importance of DNA is evident in that nearly all living organisms use it to store and transfer genetic information. Previous research has concentrated on modifying the native nucleosides found in DNA in order to modulate its function. Nucleoside modifications have focused on synthetically altering the sugar, phosphate backbone, or nucleobase. Our research is focused on nucleobase modification; converting previously investigated 5-aryl deoxyuridine analogues to the corresponding deoxycytidine analogue. These nucleosides will later be incorpoprated into short oligonucleotides for biophysical evaluation.

Synthesis of 5-aryl deoxycytidine nucleosides

245th National Meeting (2013)

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