There are millions of people that are currently infected with HIV/AIDS, yet countless contagious individuals remain unaware that they are infected.  The Center for Disease Control is presently supporting a two-year study on a free HIV antibody rapid screen test for Americans to examine if increased availability and convenience will promote HIV diagnostics and awareness1.  The antibody protein used in this test however, is less stable and costs more to produce large quantities than a small molecule with similar binding capabilities.  Small molecule HIV viral entry inhibitors have been found to be a promising new class of drugs due to the ways in which they can target protein complexes that are involved in the process of viral membrane fusion, specifically the HIV-1 glycoprotein gp120.  This research is designed to gain a fundamental understanding of small molecule HIV-1 viral entry inhibitors with synthetic linkers towards solid surface analysis of gp120.

Development of small molecule linkers towards solid surface analysis of HIV-1 viral envelope proteins

245th National Meeting (2013)

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