Since the discovery of HIV in 1981, AIDS has caused the deaths of millions of people. The current treatment requires high dosages and results in unfavorable side effects that discourage long�term use. BMS-378806 is a small molecule HIV-1 inhibitor that is preferable to the current therapy. However, little is known about the mechanism of this drug. This research aims to identify the most effective functional groups by attaching structural variations to the piperzine-adjacent phenyl ketone. These structural variants may be analyzed by isothermal titration calorimetry (ITC) to determine thermodynamically favorable binding conditions. This data may be used to construct an even more effect HIV-1 inhibitor.

Structural analysis of HIV-1 inhibitor drug candidate BMS-378806: The role of benzyl derivatives

245th National Meeting (2013)

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