Pyrrolizidine alkaloids (PA's) are potentially toxic natural secondary products found within the plant family Asteraceae. As members of the family, plants from the genera Petasites and Adenocaulon should be expected to contain PA's. We are performing analyses of P. frigidus and A. biclor samples taken from the Gorge in Oregon. We will establish PA profiles for both, previously untested plants. Preliminary GC-MS data show one major product in P. frigidus, MW 365, which is believed to be senkirkine or a novel isomeric compound. Further separation and analysis by 1D and 2D NMR experiments will be used to elucidate the identity of this alkaloid and other products present in each species.

Analysis of pyrrolizidine alkaloids in Petasites frigidus and Adenocaulon bicolor?

245th National Meeting (2013)

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