Nitrogen containing compounds are ubiquitous among all chemical industries used for various needs such as agrochemical and pharmaceutical drugs.  Often these amines are difficult to efficiently and affordably produce on a large scale.  The search for a more practical method to synthesize amines, amides and related compounds continues to be an area of prospect.  Early transition metal complexes have been shown to perform these reactions with high selectivity and reactivity.  Here we report our studies of the temperature and load dependence of using aryloxide and structurally related ligation to support titanium catalyzed hydroaminations of primary amines and activated alkynes.

Temperature and ligand load effects on titanium catalyzed hydroaminations

245th National Meeting (2013)

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