Aspergillus flavus (A. flavus) is a fungus that produces a toxic metabolite known as aflatoxin.  This fungus has infected nut crops and is responsible for the loss of millions of dollars to California's agricultural industry.  The primary objective of this project is to produce a series of ester/ether analogs for an SAR study aimed at controlling A. flavus.  The synthetic strategy features a three-step synthesis that includes reduction, esterification, and alkylation reactions.  Initial reduction and esterification steps have been accomplished on the milligram scale and products have been characterized by 1H and 13C NMR spectroscopy.  Current efforts are focused on optimizing the alkylation reaction and developing several ester/ether analogs.

Synthesis of ester/ether analogs for the inhibition of <i>A. flavus</i>

245th National Meeting (2013)

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Synthesis of ester/ether analogs for the inhibition of A. flavus