Several methods were explored to synthesize 4-acyl-3-methyl-1-phenyl-5-thiopyrazolones. Along with agricultural and medicinal uses, these compounds are used for metal ion extractions. Best results are produced when the substrate is acylated, trisylated, then nucleophilic aromatic substituted as shown below.

Synthesis of 4-acyl-5-thiopyrazolones for metal ion chelation

245th National Meeting (2013)

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