Hypervalent iodine compounds have been a great deal of interest in organic chemistry due to their mild and chemoselective oxidizing properties. Evaluation of these chiral aryl iodides calls for a substrate, which we determined to be ketophenol. The intention is to synthesize benzofurans and their derivatives, by reacting the ketophenols with hypervalent iodine compounds (in this case, iodosobenzenediacetate or equivalent) as catalyst, or with aryl iodides using an appropriate co-oxidant. We could synthesize a ketophenol, 3-(2-hydroxyphenyl)-1-phenylpropan-1-ol from dihydrocoumarin as a reagent through organometallic reactions. Yet, purification of this synthesized compound appears to be a challenging task.

Synthesis and evaluation of a new substrate for aryl iodide organocatalysis

245th National Meeting (2013)

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