Progress towards the solution phase synthesis of hairpin polyamide � FRET conjugates is reported.  These conjugates will be used to explore the potential of hairpin polyamide � FRET conjugates in DNA sequence detection.  Hairpin polyamides, PyPyPy-?-ImImIm-�-Dp and ImPyIm-?-PyImPy-�-Dp, were designed to target the DNA sequences 5'-ACCCA-3' and 5'-AGCGA-3', respectively. Hairpin polyamides were synthesized through sequential C-terminus coupling of N-methyl pyrrole and N-methyl imidazole monomeric building blocks. Coupling of completed hairpin polyamides with cyanine dyes, Cy3 and Cy5, was achieved through amide bond coupling.

Synthesis of hairpin polyamide – FRET conjugates

245th National Meeting (2013)

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