Benzofuran-containing natural products and synthetic derivatives exhibit a broad range of pharmacological activity including anticancer, antiviral, and antifungal behavior. Due to the significant biological activity, the benzofuran skeleton has been a synthetic target of several research groups.  As a result numerous synthetic approaches are available to researchers.  These methodologies include intramolecular McMurry coupling, dehydration of a-phenoxy ketones, transmetallation of 3-zinciobenzoheteroles, and electrophilic cyclization.  In an effort to extend the breath of benzofuran chemistry and provide a new handle for further modification, we have developed novel method for preparing benzofuran trifluoroborate salts by electrophilic cyclization.

Preparation of benzofuran trifluoroborate salts

245th National Meeting (2013)

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