6-Benzyl-2-thiouracil, a thyrostatic compound, is sometimes used as an illegal feed additive in Europe to make cattle grow larger, more quickly. There is interest in the use of GCMS methods for the analysis of commercial meat samples. We here report our progress towards a two-step synthesis in which the final product will be similar to the title thiouracil, differing only in the fact that there are deuterium isotopes in place of some of the hydrogen atoms. This will allow various European government agencies to use the deuterated thiouracil as an internal standard for GCMS in meat samples. We describe the following reaction as the step in which the deuterated aromatic group is incorporated.

Toward the synthesis of 6-benzyl-2-thiouracil

245th National Meeting (2013)

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