�-Fluoroamines and amides are of interest as synthetic building blocks and for their biomedical potential. A number of routes to these types of compounds are known but they require the use of hazardous materials, costly reagents and/or extended reaction times. We have been exploring a simple two step route to prepare these materials. SelectfluorTM (F-TEDA) is a safe and easy to use reagent and effectively delivers the equivalent of electrophilic fluorine to pi systems. With alkenes the reaction generates a �-fluorocarbocation which, in the absence of good nucleophiles, can be trapped by the anhydrous solvent, acetonitrile, in a Ritter type reaction to form �-fluoroamides. Subsequent hydrolysis or reduction leads to primary or secondary �-fluoroamines.

Fluorination of alkenes with Selectfluor<sup>TM</sup> (F-TEDA) to form ß-fluoroamides and amines

245th National Meeting (2013)

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Fluorination of alkenes with SelectfluorTM (F-TEDA) to form ß-fluoroamides and amines

Fluorination of alkenes with Selectfluor^TM (F-TEDA) to form ß-fluoroamides and amines