A series of carbethoxy substituted 3(2H)-furanones have been synthesized and their bioactivities against cancer cells explored. Preliminary studies show that 2-(p-chlorobenzylidene)-4-carbethoxy-5-methyl-3(2H)-furanone (I ) displays cytotoxicity against SW480 colon carcinoma cells. Additional testing will be performed to confirm the results and to measure the effect of I  against other cell lines. The syntheses and bioactivities of additional carbethoxy 3(2H)-furanones will be presented.

Synthesis of carbethoxy 3(2H)-furanones for biological studies

245th National Meeting (2013)

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