The study of catalytic cross-coupling reactions between 1-(2, 3, 4-bromo- and 2-iodophenyl)-N,N-dimethylethanamines (1  ) as electrophilic synthons and arylboronic acids (2  ) as nucleophilic synthons were performed. It was found that the optimal conditions for the reaction included the use of PdCl2(dppf) as the catalyst and water as the solvent. Water has a clear advantage because it is cheap, readily available, nontoxic, nonflammable and green. Under the above conditions, the diastereomeric aminobiaryls (4  ) with axial chirality were synthesized for the first time.

Green Suzuki-Miyaura cross-coupling for the synthesis of chiral biaryls

245th National Meeting (2013)

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