It is known that methyl-coenzyme-M reductase (MCR) is responsible for generating methane in the final step of methanogenesis. This process is facilitated by a nickel atom that resides in the center of the enzyme cofactor F430. Recently, it has been shown that this reaction is reversible and MCR has the ability to activate methane. Our goal is to design and synthesis simple F430 analogs for methane activation studies. Initial ligand designs will build off of polypyrrolic scaffolds containing substituents similar to those of F430

Bioinspired ligand design: Toward a selective catalyst for methane activation

245th National Meeting (2013)

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