Multidomain Peptides self-assemble into beta-sheet hydrogenbonded nanofibers in a way that can be easily controlled by pH or addition of appropriate counter ions. This self-assembly results in the formation of a hydrogel than can be used to effectively deliver cells or proteins such as growth factors in a combined fashion which allows one to control cellular behavior. The hydrogel can also be designed to degrade in a cell responsive fashion or can be covalently crosslinked via disulfide bond formation or enzymatically through the formation of a Schiff base. Depending on the peptide sequence used, the hydrogel undergoes sheer thinning and sheer recovery allowing the hydrogel and its contents to be easily delivered in vivo via syringe. In this talk I will describe our recent progress in the development of this fascinating molecular assembler both from the perspective of supramolecular chemistry as well as an advanced biomaterial.

Self-assembled multidomain peptide hydrogels for cell and protein delivery

245th National Meeting (2013)

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