Poly(?-(4-vinylbenzyl)-L-glutamate) (PVBLG) served as a bioactive and reactive template for the generation of a library of cationic a-helical polypeptides for gene delivery. The top performing polymer, poly(?-4-(((2-(piperidin-1-yl)ethyl)amino)methyl)benzyl-L-glutamate) (PPEABLG or PVBLG-8), outperformed 25-kDa polyethylenimine by 12-fold. Preliminary data indicates that helicity of these cationic polypeptides is essential for their improved performance, with enhanced membrane disruption a likely source of their transfection efficiency.

Helical, cationic polypeptide for gene delivery

245th National Meeting (2013)

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