Degradation and cellular proliferation properties are critical parameters in the design of new biomaterials.  Poly(glycerol sebacate) (PGS) has attracted significant interest as a resorbable polymer for tissue engineering due to its ease of synthesis and biocompatibility.  Previous studies have shown that PGS degrades by surface erosion; however, the degradation effects on surface chemistry and ultimately cell proliferation are not known.  FTIR imaging microscopy is a powerful technique for analyzing the spatial distribution of surface functionality of materials and was used to analyze the surface chemistry of PGS as a function of degradation.  In addition to surface functionality, topography plays a significant role in cell proliferation and was monitored with SEM and correlated to the surface functionality map.  Lastly, the chain length of the diacid used in the polycondensation was examined to determine the effects on polymer degradation and surface functionality and morphology.

Use of FTIR imaging and scanning electron microscopy to analyze the effects of degradation on a resorbable polyester biomaterial

245th National Meeting (2013)

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