An easy way for fabrication of �smart� nanogels for optical detection of glucose can be achieved. Bordeaux, a commercially available fluorescent dye, was adopted as a model of optical code. A copolymer microgel template poly(N-isopropylacrylamide-co-acrylic acid-co-acrylamide) [p(NIPAM-AA-AAm)] was synthesized via free radical precipitation copolymerization. PAA segments were designed to couple with boronic acid derivatives for glucose sensitivity, and PAAm segments were to tether with organic dye molecules for optical property . The glucose-induced swelling/shrinking of the microgel network regulated the fluorescence of embedded dye molecular assemblies, being able to convert chemical changes into optical signals. The dye composited microgels demonstrated good stability, as well as high selectivity to glucose over the potential interferences of lactate and human serum albumin under physiologically important glucose levels, which may have potential applications in biosensing.

Facile route for the synthesis of organic dye embedded “smart” nanogel for optical detection of glucose

245th National Meeting (2013)

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