In this lecture I will describe two efforts in our laboratory to address fundamental challenges facing the discovery of molecules, both small and large, with tailor-made activities.  These efforts are (i) the application of the powerful principles underlying biological evolution to the discovery of bioactive synthetic small molecules, and (ii) the development of a new form of directed evolution that can very rapidly generate macromolecules with desired novel activities.  Both efforts are inspired by the breathtaking effectiveness of evolution and a desire to extend its applicability to the widest possible range of problems facing science and medicine.

Chemical and biological discovery driven by evolution

245th National Meeting (2013)

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