By harnessing the power of synthetic inorganic chemistry with that of the latest nanoscience and nanotechnology, the Lin group has developed novel nanoscale coordination polymers (NCPs, also called nanoscale metal-organic frameworks, NMOFs) for multimodal imaging and anticancer drug delivery. NCPs have been shown to be excellent imaging contrast agents and drug delivery vehicles, as a result of their structural and chemical diversity, high loading capacity, and intrinsic biodegradability. They provide nontoxic and sensitive MRI, CT, and optical imaging probes for early and noninvasive detection of cancer in animal models.  The Lin group is also extending this powerful synthetic strategy to developing NCPs containing potent anticancer drugs, which can be selectively and more efficiently delivered to tumors than current chemotherapy, leading to reduced toxicity to normal cells and more effective cancer therapy. In vitro and in vivo results on NCPs that carry cisplatin, oxaliplatin, and nitrogen-containing bisphosphonates will be discussed in this talk.

Nanoscale coordination polymers for biomedical imaging and cancer therapy

245th National Meeting (2013)

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